Genetic structure of Trypanosoma cruzi in Colombia revealed by a High-throughput Nuclear Multilocus Sequence Typing (nMLST) approach
Identifieur interne : 000343 ( Main/Exploration ); précédent : 000342; suivant : 000344Genetic structure of Trypanosoma cruzi in Colombia revealed by a High-throughput Nuclear Multilocus Sequence Typing (nMLST) approach
Auteurs : Juan David Ramírez [Colombie] ; Gabriela Tapia-Calle [Colombie] ; Felipe Guhl [Colombie]Source :
- BMC Genetics [ 1471-2156 ] ; 2013.
Abstract
Chagas disease is a systemic pathology caused by
We conducted a spatial and temporal analysis on 50 biological clones of
These findings reinforce the emergence of an enigmatic domestic
Url:
DOI: 10.1186/1471-2156-14-96
PubMed: 24079755
PubMed Central: 3850472
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Genetic structure of <italic>Trypanosoma cruzi</italic> in Colombia revealed by a High-throughput Nuclear Multilocus Sequence Typing (nMLST) approach</title><author><name sortKey="Ramirez, Juan David" sort="Ramirez, Juan David" uniqKey="Ramirez J" first="Juan David" last="Ramírez">Juan David Ramírez</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Tapia Calle, Gabriela" sort="Tapia Calle, Gabriela" uniqKey="Tapia Calle G" first="Gabriela" last="Tapia-Calle">Gabriela Tapia-Calle</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Guhl, Felipe" sort="Guhl, Felipe" uniqKey="Guhl F" first="Felipe" last="Guhl">Felipe Guhl</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24079755</idno><idno type="pmc">3850472</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3850472</idno><idno type="RBID">PMC:3850472</idno><idno type="doi">10.1186/1471-2156-14-96</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000329</idno><idno type="wicri:Area/Pmc/Curation">000329</idno><idno type="wicri:Area/Pmc/Checkpoint">000323</idno><idno type="wicri:Area/Ncbi/Merge">000452</idno><idno type="wicri:Area/Ncbi/Curation">000452</idno><idno type="wicri:Area/Ncbi/Checkpoint">000452</idno><idno type="wicri:Area/Main/Merge">000344</idno><idno type="wicri:Area/Main/Curation">000343</idno><idno type="wicri:Area/Main/Exploration">000343</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Genetic structure of <italic>Trypanosoma cruzi</italic> in Colombia revealed by a High-throughput Nuclear Multilocus Sequence Typing (nMLST) approach</title><author><name sortKey="Ramirez, Juan David" sort="Ramirez, Juan David" uniqKey="Ramirez J" first="Juan David" last="Ramírez">Juan David Ramírez</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Tapia Calle, Gabriela" sort="Tapia Calle, Gabriela" uniqKey="Tapia Calle G" first="Gabriela" last="Tapia-Calle">Gabriela Tapia-Calle</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author><author><name sortKey="Guhl, Felipe" sort="Guhl, Felipe" uniqKey="Guhl F" first="Felipe" last="Guhl">Felipe Guhl</name><affiliation wicri:level="1"><nlm:aff id="I1">Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá, Colombia</nlm:aff><country xml:lang="fr">Colombie</country><wicri:regionArea>Centro de Investigaciones en Microbiología y Parasitología Tropical (CIMPAT), Universidad de Los Andes, Bogotá</wicri:regionArea><wicri:noRegion>Bogotá</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Genetics</title><idno type="eISSN">1471-2156</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Chagas disease is a systemic pathology caused by <italic>Trypanosoma cruzi</italic>. This parasite reveals remarkable genetic variability, evinced in six Discrete Typing Units (DTUs) named from <italic>T. cruzi</italic> I to <italic>T. cruzi</italic> VI (TcI to TcVI). Recently newly identified genotypes have emerged such as TcBat in Brazil, Colombia and Panama associated to anthropogenic bats. The genotype with the broadest geographical distribution is TcI, which has recently been associated to severe cardiomyopathies in Argentina and Colombia. Therefore, new studies unraveling the genetic structure and natural history of this DTU must be pursued.</p></sec><sec><title>Results</title><p>We conducted a spatial and temporal analysis on 50 biological clones of <italic>T. cruzi</italic> I (TcI) isolated from humans with different clinical phenotypes, triatomine bugs and mammal reservoirs across three endemic regions for Chagas disease in Colombia. These clones were submitted to a nuclear Multilocus Sequence Typing (nMLST) analysis in order to elucidate its genetic diversity and clustering. After analyzing 13 nuclear housekeeping genes and obtaining a 5821 bp length alignment, we detected two robust genotypes within TcI henceforth named TcI<sub>DOM</sub> (associated to human infections) and a second cluster associated to peridomestic and sylvatic populations. Additionaly, we detected putative events of recombination and an intriguing lack of linkage disequilibrium.</p></sec><sec><title>Conclusions</title><p>These findings reinforce the emergence of an enigmatic domestic <italic>T. cruzi</italic> genotype (TcI<sub>DOM</sub>), and demonstrates the high frequency of recombination at nuclear level across natural populations of <italic>T. cruzi</italic>. Therefore, the need to pursue studies focused on the diferential virulence profiles of TcI strains. 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sortKey="Ramirez, Jd" uniqKey="Ramirez J">JD Ramírez</name></author><author><name sortKey="Herrera, C" uniqKey="Herrera C">C Herrera</name></author><author><name sortKey="Bogota, Y" uniqKey="Bogota Y">Y Bogotá</name></author><author><name sortKey="Duque, Mc" uniqKey="Duque M">MC Duque</name></author><author><name sortKey="Suarez Rivilla, A" uniqKey="Suarez Rivilla A">A Suárez-Rivilla</name></author><author><name sortKey="Guhl, F" uniqKey="Guhl F">F Guhl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, Md" uniqKey="Lewis M">MD Lewis</name></author><author><name sortKey="Yeo, M" uniqKey="Yeo M">M Yeo</name></author><author><name sortKey="Carrasco, Hj" uniqKey="Carrasco H">HJ Carrasco</name></author><author><name sortKey="Llewellyn, Ms" uniqKey="Llewellyn M">MS Llewellyn</name></author><author><name sortKey="Miles, Ma" uniqKey="Miles M">MA Miles</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haubold, B" uniqKey="Haubold B">B Haubold</name></author><author><name sortKey="Hudson, Rr" uniqKey="Hudson R">RR Hudson</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Colombie</li></country></list><tree><country name="Colombie"><noRegion><name sortKey="Ramirez, Juan David" sort="Ramirez, Juan David" uniqKey="Ramirez J" first="Juan David" last="Ramírez">Juan David Ramírez</name></noRegion><name sortKey="Guhl, Felipe" sort="Guhl, Felipe" uniqKey="Guhl F" first="Felipe" last="Guhl">Felipe Guhl</name><name sortKey="Tapia Calle, Gabriela" sort="Tapia Calle, Gabriela" uniqKey="Tapia Calle G" first="Gabriela" last="Tapia-Calle">Gabriela Tapia-Calle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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